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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
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Understanding Patient and Physician Perspectives Regarding Innovative Research in Rheumatoid Arthritis.

Melanie C Baniña1, Radhika Prabhune1, Catney Charles1

  • 1M.C. Baniña, PhD, R. Prabhune, MHSc, C. Charles, BS, M. Hudson, MD, MPH, Lady Davis Institute, and Jewish General Hospital, Montreal.

The Journal of Rheumatology
|September 15, 2025
PubMed
Summary
This summary is machine-generated.

Patients and physicians expressed concerns about how research participation could disrupt daily life and shared decision-making in rheumatoid arthritis (RA) care. Understanding these perspectives is crucial for the success of innovative RA research, including pragmatic randomized clinical trials (pRCTs).

Keywords:
biomarker-driven trialsembedded qualitative designpatient perspectivesphysician perspectivespragmatic clinical trialsrheumatoid arthritis

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Area of Science:

  • Rheumatology
  • Clinical Research
  • Patient Engagement

Background:

  • Optimal rheumatoid arthritis (RA) treatment remains undetermined.
  • Novel research approaches like pragmatic randomized clinical trials (pRCTs) and biomarker-driven trials are needed for personalized RA care.
  • Patient and physician perspectives on these innovative research methods are understudied.

Purpose of the Study:

  • To explore patient and physician views on innovative RA research methods.
  • To identify potential challenges and facilitators for implementing pragmatic randomized clinical trials (pRCTs) and biomarker-driven trials in RA clinical care.
  • To enhance the success of future RA research innovations by incorporating end-user insights.

Main Methods:

  • Conducted 3 focus groups with 17 RA patients and 1 focus group with 5 rheumatologists.
  • Discussions focused on challenges in innovative RA research within a larger pRCT.
  • Thematic analysis was performed using a self-management framework and patient engagement perspective.

Main Results:

  • Patient themes included preferences for decision-making information, managing treatment challenges, and the patient-physician relationship.
  • Physician themes covered research impact on management, trial feasibility (pRCTs, biomarker-driven), and randomization's effect on shared decision-making.
  • Both groups expressed concerns about research disrupting daily activities and shared decision-making.

Conclusions:

  • Patient and physician concerns highlight potential disruptions to daily life and shared decision-making in clinical research settings.
  • Incorporating patient and physician perspectives on pRCTs and biomarker-driven trials is vital for research innovation success.
  • Addressing these concerns can improve the integration of innovative research into RA clinical practice.