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Updated: Jan 17, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
How to Manage Cardiovascular Disease in Psoriatic Disease: Evidence and Time Management in Clinic
Maria-Angeliki Gkini1, Pamela Diaz2, Cheryl F Rosen3
1M.A. Gkini, MD, MSc, PhD, Department of Dermatology, Barts Health NHS Trust, London, UK; Maria-Angeliki.Gkini@nhs.net pjdiaz@uc.cl.
Insights
Early cardiovascular disease (CVD) recognition is vital for patients with psoriatic disease (PsD). Comprehensive assessment and management, involving multiple specialists, are crucial for preventing morbidity and mortality, despite practical challenges.
Area of Science:
- Rheumatology
- Cardiology
- Dermatology
Background:
- Psoriatic disease (PsD) and cardiovascular disease (CVD) share inflammatory pathways, increasing patient risk.
- Early identification and management of CVD in PsD patients are critical for reducing morbidity and mortality.
Purpose of the Study:
- To highlight the importance of cardiovascular risk assessment in psoriatic disease patients.
- To outline strategies for the comprehensive management of cardiovascular comorbidities in PsD.
Main Methods:
- Review of shared pathogenic mechanisms between PsD and CVD.
- Assessment strategies including clinical history, risk factors, blood tests, and imaging.
- Multidisciplinary approach involving primary care, internal medicine, cardiology, dermatology, and rheumatology.
Main Results:
- PsD and CVD share proinflammatory cytokine pathways (e.g., tumor necrosis factor).
- Comprehensive assessment should include clinical evaluation, risk factors (diabetes, hypertension, dyslipidemia), and diagnostic tests.
- Multidisciplinary management and lifestyle interventions are essential.
Conclusions:
- Routine cardiovascular assessment and management are recommended for all PsD patients.
- Effective management requires collaboration among various medical specialists and addressing practical challenges.
- Further research is needed to clarify CVD risk modification with PsD treatment remission.
Abstract:
Early recognition and appropriate management of cardiovascular (CV) disease (CVD) in patients with psoriatic disease (PsD) is critical for prevention of early morbidity and mortality. PsD and CVD share common pathogenic mechanisms, including upregulation of proinflammatory cytokines like tumor necrosis factor. Potential CV comorbidities should be assessed in all patients with PsD through clinical history, risk factor assessment (eg, diabetes, hypertension, dyslipidemia), blood tests, and imaging, when required. Collaboration with the patient's primary care physician is essential, offering preventive measures such as healthy lifestyle advice (eg, diet, exercise, weight loss, smoking and drinking cessation). Management of comorbid conditions requires a multidisciplinary setting of family doctors, internists, cardiologists, dermatologists, and rheumatologists. Treating psoriatic arthritis and psoriasis to remission is recommended; however, the data on CVD risk modification remain inconclusive, necessitating further studies. Thus, routine CVD assessment and management should be provided to patients with PsD, despite practical difficulties such as clinical time constraints and lack of support staff. The evidence and experiences of a dermatologist and rheumatologist assessing and managing CVD in clinic were presented at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2024 annual meeting.
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