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Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
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Brainwaves meet soundwaves: ultrasound stimulation for treating major depressive disorder by targeting the

Ahsan Khan1,2,3, Desmond J Oathes4,5,6,7

  • 1Center for Brain Imaging and Stimulation, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|September 15, 2025
PubMed
Abstract

No abstract available in PubMed .

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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
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