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Related Concept Videos

Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Updated: Jun 14, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Multifunctional Nanocarrier Drug Delivery Systems: From Diverse Design to Precise Biomedical Applications.

Yan-Fei Zhu1, Meng-Qi He1, Cai-Shi Lin1

  • 1State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, P. R. China.

Advanced Healthcare Materials
|September 16, 2025
PubMed
Summary
This summary is machine-generated.

Multifunctional nanocarrier drug delivery systems (MNDDS) offer precision targeting for complex diseases. This review explores MNDDS platforms, payloads, targeting strategies, and applications, advancing precision medicine.

Keywords:
drug deliverymultifunctional nanocarrier drug delivery systemsnanocarriersprecision medicinetargeted modification

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Conventional therapies struggle with complex diseases.
  • Multifunctional nanocarrier drug delivery systems (MNDDS) offer advanced solutions.
  • MNDDS enable precision medicine through controlled drug delivery.

Purpose of the Study:

  • To review the latest advancements in MNDDS.
  • To classify MNDDS platforms and therapeutic payloads.
  • To highlight engineering strategies and applications for disease treatment.

Main Methods:

  • Classification of nanocarrier platforms (biological and non-biological).
  • Summarization of diverse therapeutic payloads (chemical, protein, nucleic acid).
  • Elaboration of active and passive targeting strategies via structural modifications.

Main Results:

  • MNDDS integrate various payloads and targeting mechanisms.
  • Applications span diverse disease treatments.
  • Emerging strategies focus on bioinspired design and theranostics.

Conclusions:

  • MNDDS are crucial for overcoming therapeutic limitations.
  • Advancements in MNDDS facilitate precision medicine.
  • Future directions include intelligent design and personalized microenvironment engineering.