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Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration

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Advanced Multifunctional Bioactive Glass Nanoparticles: from Tissue Repair to Theranostics.

Yanzi Zhao¹, Weipeng Qiang¹, Bo Lei^1,2,3,4

¹Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University,Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, P. R. China.

Advanced Healthcare Materials

|September 16, 2025

Summary

This summary is machine-generated.

Multifunctional bioactive glass nanoparticles (BGNs) show promise in various biomedical applications, including tissue repair and theranostics. This review covers their structure, preparation, functionalization, and diverse clinical uses.

Keywords:

bioactive glass nanoparticles integrated diagnosis and treatment multi‐functional tissue repair

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Area of Science:

Biomaterials Science
Nanotechnology
Biomedical Engineering

Background:

Multifunctional bioactive glass nanoparticles (BGNs) are gaining attention for their biocompatibility and versatility.
Their nanoscale properties enable diverse biomedical functions, from tissue regeneration to targeted therapies.

Purpose of the Study:

To review recent advancements in multifunctional BGNs.
To summarize their physicochemical properties, preparation, and functionalization strategies.
To explore their broad biomedical applications, including theranostics.

Main Methods:

Comprehensive literature review of multifunctional BGNs.
Analysis of BGNs' structural design and functionalization.
Summary of applications in tissue repair, bioimaging, drug/gene delivery, and tumor therapy.

Main Results:

Detailed overview of BGNs' structure-property relationships.
Compilation of various preparation and functionalization techniques.
Demonstration of BGNs' efficacy in diverse biomedical applications, including integrated therapeutic-repair platforms.

Conclusions:

Multifunctional BGNs offer significant potential for advanced biomedical applications.
Further research into structural optimization and functionalization will enhance clinical translation.
BGNs are promising candidates for theranostics and regenerative medicine.