Efficiency-fluctuation trade-offs in biomolecular assembly processes
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View abstract on PubMed
Summary
This summary is machine-generated.Cellular processes exhibit unavoidable trade-offs between assembly efficiency and molecular fluctuations. Combining feedback control with distinct subunit synthesis rates is necessary to overcome this generalized efficiency-fluctuation trade-off.
Area Of Science
- Systems Biology
- Biophysics
- Molecular Biology
Background
- Stochastic fluctuations in molecular abundances cause cell-to-cell variability.
- Previous studies suggested an efficiency-fluctuation trade-off in cellular assembly processes.
- Contradictory findings on noise filtering properties of efficient assembly processes prompted further investigation.
Purpose Of The Study
- To investigate the applicability of the efficiency-fluctuation trade-off in a broader range of assembly processes.
- To determine conditions for overcoming the trade-off and mitigating molecular fluctuations.
- To reconcile conflicting results regarding noise filtering in efficient assembly.
Main Methods
- Theoretical analysis of reaction dynamics in cellular networks.
- Examination of generalized assembly processes with arbitrary interactions.
- Numerical simulations to illustrate control strategies and their effects.
Main Results
- A broader class of assembly processes is subject to an efficiency-fluctuation trade-off diverging at high efficiency.
- Efficient assembly processes acting as noise filters represent a singular limit.
- Overcoming the trade-off requires combining feedback control with distinct subunit synthesis rates.
Conclusions
- The efficiency-fluctuation trade-off is a general feature of many cellular assembly processes.
- Biomolecular integral controllers exemplify strategies to overcome this trade-off.
- The precise control adjustments needed to avoid diverging fluctuations remain an open question.
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