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Extending Selective Arrays for Infectious Disease Detection.

Josselyn Mata Calidonio1, Kevin J Mathewson1, Kimberly Hamad-Schifferli1

  • 1Department of Engineering, University of Massachusetts Boston, MA 100 Morrissey Blvd, Boston, Massachusetts 02125, United States.

Analytical Chemistry
|September 16, 2025
PubMed
Summary
This summary is machine-generated.

Artificial nose technology, or selective sensor arrays, can detect diseases. This perspective explores using these powerful diagnostic tools for identifying a wide range of pathogens and unknown infectious agents.

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Area of Science:

  • Biotechnology
  • Sensor Technology
  • Infectious Disease Diagnostics

Background:

  • Selective sensor arrays, known as "artificial noses," excel at detecting small molecules using pattern recognition.
  • Current applications focus on chemical and environmental sensing, with limited exploration in biological targets.

Purpose of the Study:

  • To advocate for the application of artificial nose systems in infectious disease diagnostics.
  • To highlight the potential of these arrays for detecting a broad spectrum of pathogens.

Main Methods:

  • Utilizing cross-reactive, pattern-based recognition principles inherent in selective sensor arrays.
  • Extending the established chemolfactory array methodology to biological sensing.

Main Results:

  • Artificial nose systems offer a novel approach to infectious disease detection.
  • The technology allows for the identification of diverse pathogens and unknown agents.

Conclusions:

  • The application of artificial nose technology to infectious disease diagnostics presents significant advantages.
  • This approach bypasses the need for highly specific recognition elements, enabling broader detection capabilities.