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Updated: Jan 17, 2026

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
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Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

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The Emerging Roles of Nano Drug Delivery Systems in Treatment of Osteoporosis-Current Knowledge, Challenges and

Peng Yin1,2, Shilin Dong1,2,3, Jiaoyang Yu1,2

  • 1Department of Orthopaedic Trauma, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China.

International Journal of Nanomedicine
|September 16, 2025
PubMed

Insights

Nano-drug delivery systems (NDDSs) offer targeted osteoporosis (OP) treatment, overcoming side effects of traditional drugs. This review covers NDDS strategies and efficacy for next-generation OP nanomedicines.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Osteoporosis (OP) is a bone disease causing fragility and fractures.
  • Current OP drugs have limitations, including off-target effects and side effects.
  • Nano-drug delivery systems (NDDSs) show promise for targeted OP therapy.

Purpose of the Study:

  • To systematically review recent applications of NDDSs in osteoporosis treatment.
  • To focus on targeting strategies, efficacy validation, and clinical translation of NDDSs for OP.
  • To provide insights for developing next-generation targeted nanomedicines for OP.

Main Methods:

  • Review of inorganic, organic, biogenic, and hybrid NDDSs for OP treatment.
  • Analysis of targeting design strategies in NDDSs for OP.
  • Evaluation of in vitro and in vivo efficacy of NDDSs in OP models.

Main Results:

  • NDDSs demonstrate high drug loading, targeting ability, and biocompatibility for OP.
  • Various NDDS formulations show significant therapeutic potential in preclinical studies.
  • Challenges in clinical translation of NDDSs for OP remain.

Conclusions:

  • NDDSs represent a promising approach for targeted osteoporosis therapy.
  • Further research is needed to overcome clinical translation challenges for NDDSs in OP.
  • NDDSs hold potential for improved osteoporosis management with reduced side effects.
Keywords:
nano-drug delivery systemsnanomaterialsnanoparticlesosteoporosistargeted therapy

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