Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Jet fuel and liver function.

M Døssing, S Loft, E Schroeder

    Scandinavian Journal of Work, Environment & Health
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Occupational exposure to jet fuel significantly enhances antipyrine elimination in fuel-filling attendants, indicating jet fuel acts as an inducer of hepatic drug metabolism in humans.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Birth Cohort Studies of Long-Term Exposure to Ambient Air Pollution in Early Life and Development of Asthma in Children and Adolescents from Denmark.

    Research report (Health Effects Institute)·2024
    Same author

    Long-Term Exposure to AIR Pollution and COVID-19 Mortality and Morbidity in DENmark: Who Is Most Susceptible? (AIRCODEN).

    Research report (Health Effects Institute)·2024
    Same author

    Ultrafine particle exposure for bicycle commutes in rush and non-rush hour traffic: A repeated measures study in Copenhagen, Denmark.

    Environmental pollution (Barking, Essex : 1987)·2021
    Same author

    Exposure to ultrafine particles while walking or bicycling during COVID-19 closures: A repeated measures study in Copenhagen, Denmark.

    The Science of the total environment·2021
    Same author

    Household dampness and microbial exposure related to allergy and respiratory health in Danish adults.

    European clinical respiratory journal·2020
    Same author

    Metaphyeal and Diaphyseal Dysplasia of the Third Cervical Vertebra Secondary to Physeal Necrosis in a Quarter Horse Foal.

    Journal of comparative pathology·2018
    Same journal

    Employer-provided bicycle benefit and changes in commuting and overall physical activity: A quasi-experiment among Finnish municipal employees.

    Scandinavian journal of work, environment & health·2026
    Same journal

    Genomic insights into somatic mutations from occupational exposure to low-dose ionizing radiation.

    Scandinavian journal of work, environment & health·2026
    Same journal

    Mental health problems and suicidal behaviors in person-related work: a Swedish register-based cohort study.

    Scandinavian journal of work, environment & health·2026
    Same journal

    Relative risk and excess fraction of preterm birth across maternal occupation and industry: a Danish nationwide register-based cohort study of employed pregnant women.

    Scandinavian journal of work, environment & health·2026
    Same journal

    Job strain and ischemic heart disease: the balance of methodological bias and implications for prevention. Response to: Bonde JP et al. The demands-control-support work stress model and risk of ischemic heart disease: causal inference based on observational epidemiology.

    Scandinavian journal of work, environment & health·2026
    Same journal

    Employment and working conditions and risk of suicidal behaviors: a systematic review and meta-analysis of longitudinal studies.

    Scandinavian journal of work, environment & health·2026
    See all related articles

    Area of Science:

    • Occupational Health
    • Pharmacokinetics
    • Toxicology

    Background:

    • Occupational exposure to complex solvent mixtures like jet fuel is common in certain industries.
    • Understanding the metabolic impact of such exposures is crucial for assessing health risks.

    Purpose of the Study:

    • To investigate the effect of occupational jet fuel exposure on the metabolic clearance of antipyrine in humans.
    • To determine if jet fuel acts as an inducer of hepatic drug metabolism.

    Main Methods:

    • Studied 91 fuel-filling attendants and 47 office workers (controls).
    • Measured antipyrine clearance during and after occupational exposure periods.
    • Monitored jet fuel concentration in the breathing zone and assessed liver enzyme levels.

    Related Experiment Videos

    Main Results:

    • Mean antipyrine clearance was significantly higher (68.4 ml/min) during jet fuel exposure compared to post-exposure (57.9 ml/min).
    • Office workers showed lower baseline antipyrine clearance (62.7 ml/min) which decreased after an exposure-free period (56.4 ml/min).
    • No significant differences in serum aspartate aminotransferase or alkaline phosphatase were observed between groups.

    Conclusions:

    • Jet fuel, a mixture of organic solvents, is an inducer of hepatic drug metabolism in humans.
    • Occupational exposure to jet fuel can alter drug metabolism rates.