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Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
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Impact of Extended Lens-Induced Myopia on Retinal Structure and Function in Mice
Yajing Yang1,2,3, Yohei Tomita1,2,3, Deokho Lee1,2,3
1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Current Eye Research
|September 16, 2025
Summary
Prolonged myopia in mice causes time-dependent changes in retinal structure and function, especially in inner retinal layers. Early monitoring is crucial for managing myopia-related retinal alterations.
Area of Science:
- Ophthalmology
- Retinal Biology
- Animal Models
Background:
- Myopia is a growing global health concern.
- Understanding the long-term effects of myopia on retinal structure and function is critical.
Purpose of the Study:
- To investigate time-dependent structural and functional retinal alterations in a mouse model of prolonged lens-induced myopia.
Main Methods:
- Myopia was induced in mice using -30 D lenses.
- Ocular parameters (refraction, axial length, choroidal/retinal thickness) were measured.
- Retinal function was assessed using electroretinography.
Main Results:
- Prolonged myopia led to reduced refraction, increased axial length, and thinner choroids.
- Inner retinal thickness was significantly reduced.
- Electroretinography showed impaired retinal function.
Conclusions:
- Lens-induced myopia causes progressive retinal changes in mice.
- This model highlights the inner retina's vulnerability to prolonged myopia.
- Early monitoring and intervention strategies are essential for myopia management.
