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Changes in bacterial sexually transmitted infections among men who have sex with men using pre-exposure prophylaxis

Martha G Normallairy1, Nadia Hanum1,2, Miasari Handayani3

  • 1Department of Pharmacology and Clinical Pharmacy, School of Pharmacy - Bandung Institute of Technology, Bandung, Indonesia.

International Journal of STD & AIDS
|September 16, 2025
PubMed

Insights

This study on HIV pre-exposure prophylaxis (PrEP) for men who have sex with men (MSM) in Indonesia found increasing STI prevalence, linked to changes in sexual behaviors like inconsistent condom use.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Sexual Health

Background:

  • HIV pre-exposure prophylaxis (PrEP) is crucial for key populations.
  • Understanding STI trends among MSM on PrEP is vital for public health strategies.

Purpose of the Study:

  • To assess STI incidence, prevalence, and associated factors among MSM using PrEP in West Java, Indonesia.
  • To analyze changes in sexual behaviors during the PrEP pilot program.

Main Methods:

  • Prospective, real-world implementation study of the Indonesia PrEP pilot program.
  • Data collected from 311 MSM on HIV tests, sexual behaviors, and STIs via baseline and quarterly follow-ups (2021-2023).

Main Results:

  • STI prevalence increased from 8.57% at month 3 to 12.5% at month 12.
  • STI incidence rate was 15.4 per 100 person-years; factors associated with STIs included prior STI history and condom use.
  • Inconsistent condom use increased, while multiple partners and condomless sex decreased.

Conclusions:

  • STI prevalence among MSM on PrEP in West Java increased but remained below pre-PrEP levels.
  • Changes in sexual behaviors, including inconsistent condom use, were associated with observed STI trends.
Keywords:
Asia < locationHIV (human immunodeficiency virus) < viral diseasePrevention < otherhomosexual < othersexual behaviour < other

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