Newer Therapies for Osteoporosis: A Systematic Review
Parthajit Das1, Mohit Goyal2, Debaditya Roy3
1Rheumatologist, Department of Rheumatology, Asian Institute of Immunology and Rheumatology, Kolkata, West Bengal, India, Orcid: https://orcid.org/0000-0002-1788-846X, Corresponding Author.
The Journal of the Association of Physicians of India
|September 16, 2025
Summary
Newer osteoporosis treatments, including anabolic agents like abaloparatide and romosozumab, show significant bone mineral density gains and fracture risk reduction in men and postmenopausal women. These novel therapies offer greater efficacy than older options.
Area of Science:
- Endocrinology
- Bone Metabolism
- Pharmacology
Background:
- Osteoporosis management faces unmet needs, driving demand for novel therapeutic agents.
- Emerging treatments and targets are crucial for improving patient outcomes in osteoporosis care.
Purpose of the Study:
- To critically appraise the evidence on the efficacy of newer osteoporosis therapies.
- To evaluate the impact of novel agents on bone mineral density and fracture incidence.
Main Methods:
- Systematic review of randomized controlled trials (RCTs) from 2013-2023 across Scopus, Embase, and MEDLINE.
- Analysis of bone mineral density (BMD) changes and fracture reduction (vertebral and nonvertebral).
- Assessment of methodological quality using the Oxford scoring system.
Main Results:
- Eighteen RCTs involving 23,341 participants (22,868 postmenopausal women, 473 men) were included.
- Abaloparatide and romosozumab demonstrated significant BMD gains and fracture risk reduction, outperforming teriparatide.
- Blosozumab showed substantial BMD increases; sequential anabolic-then-antiresorptive therapy was more effective than the reverse.
Conclusions:
- Novel osteoporosis therapies significantly enhance BMD and reduce fracture risk in men and postmenopausal women.
- Newer anabolic agents represent a more efficacious treatment option compared to existing therapies.
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