Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.4K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.4K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.2K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

COG5-congenital disorder of glycosylation diagnosed by whole genome sequencing in siblings with unexplained optic atrophy, macular atrophy, and developmental delay: case report.

Frontiers in neurology·2026
Same author

Dupilumab as an effective therapy for eosinophilic esophagitis in pediatric patients weighing less than 15 kilograms.

JPGN reports·2026
Same author

Septal fibroma as an unusual cause for variable heart block in a well infant.

HeartRhythm case reports·2026
Same author

A novel truncating variant in <i>PRDM16</i> causes severe familial cardiomyopathy with variable clinical presentations.

Genes & diseases·2026
Same author

Placental hypoplasia and vascular malperfusion are associated with reduced brain volumes in fetal congenital heart disease.

Pediatric research·2026
Same author

Gestational Alloimmune Liver Disease and Congenital Athymia in a Neonate Born via In Vitro Fertilization Surrogacy.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2025

Related Experiment Video

Updated: Jan 17, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

2.2K

High-Grade Malignant Pleuropulmonary Neoplasm With YAP1::MAML2 Gene Fusion.

Shengmei Zhou1,2, Ryan Schmidt1,2, Paul Zamiara1,2

  • 1Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, CA, USA.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
|September 16, 2025
PubMed
Summary

A rare pediatric lung cancer, pleuropulmonary blastoma (PPB), was found to have a novel YAP1::MAML2 gene fusion. This discovery offers new insights into the molecular basis of this aggressive thoracic neoplasm.

Keywords:
DICER1TP53YAP1::MAML2 gene fusionmalignant pleuropulmonary neoplasmspleuropulmonary blastomatype III pleuropulmonary blastoma

More Related Videos

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
09:49

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Published on: July 5, 2019

10.0K
All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
09:55

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System

Published on: December 20, 2021

3.3K

Related Experiment Videos

Last Updated: Jan 17, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

2.2K
Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
09:49

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Published on: July 5, 2019

10.0K
All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
09:55

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System

Published on: December 20, 2021

3.3K

Area of Science:

  • Pediatric Oncology
  • Thoracic Surgery
  • Molecular Pathology

Background:

  • Pleuropulmonary blastoma (PPB) is a rare and aggressive pediatric lung tumor.
  • Accurate diagnosis and understanding of PPB's molecular drivers are crucial for effective treatment.
  • Previous research has focused on DICER1 and TP53 mutations in PPB.

Purpose of the Study:

  • To report a unique case of a pediatric thoracic neoplasm with an unusual presentation.
  • To investigate the molecular characteristics of a pleuropulmonary blastoma (PPB)-like tumor.
  • To identify novel genetic alterations in pediatric lung neoplasms.

Main Methods:

  • Case presentation of a 17-month-old male with a large intrathoracic mass and metastases.
  • Histopathological and immunohistochemical analysis of tumor biopsy.
  • Comprehensive molecular analysis including gene fusion detection and copy number profiling.

Main Results:

  • The tumor exhibited features suggestive of, but not typical for, type III pleuropulmonary blastoma (PPB).
  • A YAP1::MAML2 gene fusion was identified, a novel finding in pleuropulmonary neoplasms.
  • The patient had a complex copy number profile but no DICER1 or TP53 mutations.

Conclusions:

  • This case represents the first report of a YAP1::MAML2 gene fusion in a pleuropulmonary neoplasm.
  • The identified gene fusion may represent a new molecular subtype or driver in pediatric lung cancers.
  • Further research is warranted to explore the role of YAP1::MAML2 fusions in thoracic malignancies.