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Related Experiment Video

Updated: Jan 17, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

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Autonomic function effects on postoperative sleep disorder: a prospective cohort study.

Yunda Fang^1,2, Yan Zhang³, Gang Wang^1,2

¹Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

International Journal of Surgery (London, England)

|September 16, 2025

Summary

Heart rate variability (HRV) can identify patients at risk for postoperative sleep disorders (PSD). This study used HRV to develop a model for early PSD detection, aiding surgical recovery.

Keywords:

autonomic nervous system digital biomarker enhanced recovery after surgery heart rate variability postoperative sleep disorder

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Area of Science:

Cardiology
Sleep Medicine
Surgical Recovery

Background:

Postoperative sleep disorders (PSD) are common surgical complications.
Early PSD identification is crucial for reducing surgical stress and enhancing recovery.
Current methods for PSD risk assessment are limited.

Purpose of the Study:

To investigate heart rate variability (HRV) as a digital biomarker for PSD.
To develop a predictive model for early PSD identification using HRV.
To assess autonomic nervous system regulation in patients with and without PSD.

Main Methods:

Assessed 120-hour continuous HRV in 51 gastrointestinal cancer surgery patients.
Compared HRV parameters between patients with and without PSD.
Developed a risk factor prediction model using HRV parameters.

Main Results:

Patients with PSD showed lower parasympathetic tone and disrupted autonomic circadian rhythms.
The predictive model achieved an AUC of 0.815, sensitivity of 0.909, and specificity of 0.621.
HRV parameters effectively differentiated patients with and without PSD.

Conclusions:

HRV is a valuable non-invasive tool for diagnosing PSD risk.
HRV monitoring can improve perioperative sleep quality management.
This approach holds potential for expanded use in the perioperative period.