Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Considering management context when investigating behavioral profiles in a group of captive Javan gibbons (<i>Hylobates moloch</i>).

Journal of applied animal welfare science : JAAWS·2024

Same author

Longitudinal changes in juvenile and adolescent body mass indices before, during, and after the COVID-19 lockdown in New Zealand.

American journal of human biology : the official journal of the Human Biology Council·2023

Same author

Dental biorhythm is associated with adolescent weight gain.

Communications medicine·2022

Same author

Enamel daily secretion rates of deciduous molars from a global sample of children.

Archives of oral biology·2021

Same author

Technical note: Estimating original crown height in worn mandibular canines using aspects of dentin morphology.

American journal of physical anthropology·2021

Same author

An inconstant biorhythm: The changing pace of Retzius periodicity in human permanent teeth.

American journal of physical anthropology·2020

Search research articles

Related Experiment Video

Updated: May 7, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Osteoarthritis at Roonka, Australia: A Local Biology.

Matilda McVicar¹, Bruce Floyd¹, Judith Littleton¹

¹Anthropology, School of Social Sciences, University of Auckland, Auckland, New Zealand.

American Journal of Biological Anthropology

|September 16, 2025

Summary

Osteoarthritis (OA) was not prevalent in the Roonka population, differing from expectations. This study highlights how biology and culture influence OA

Keywords:

Australia Hunter‐gatherers bioarchaeology local biologies osteoarthritis

More Related Videos

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Author Spotlight: Using a Rabbit Model to Explore the Efficacy of Tuina in Treating Knee Osteoarthritis

Author Spotlight: Using a Rabbit Model to Explore the Efficacy of Tuina in Treating Knee Osteoarthritis

Published on: August 25, 2023

Related Experiment Videos

Last Updated: May 7, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Author Spotlight: Using a Rabbit Model to Explore the Efficacy of Tuina in Treating Knee Osteoarthritis

Author Spotlight: Using a Rabbit Model to Explore the Efficacy of Tuina in Treating Knee Osteoarthritis

Published on: August 25, 2023

Area of Science:

Palaeopathology
Bioarchaeology
Human Osteology

Background:

Osteoarthritis (OA) is often considered an inevitable aspect of aging.
Palaeopathological studies offer insights into past health conditions and challenge universal biological assumptions.
The Roonka site in South Australia provides a Holocene record for examining OA patterns.

Purpose of the Study:

To analyze osteoarthritis (OA) in human remains from the Roonka site.
To test whether OA patterns align with contemporary, ethnohistorical, and archaeological expectations.
To investigate if OA at Roonka was distinct from other populations.

Main Methods:

Analysis of 83 adult human remains from Roonka, South Australia, spanning early and late Holocene periods.
Standardized criteria (Waldron and Rogers, 1995) were used to define and assess OA.
Statistical analysis included univariate and quasi-Poisson regression.

Main Results:

Osteoarthritis (OA) was rare, primarily affecting the temporomandibular joint (TMJ) (28.8%) and upper body.
Lower body OA was predominantly observed in individuals with pre-existing injuries or diseases.
Patterns showed similarities to other Murray River populations but with notable spatial diversity.

Conclusions:

The Roonka OA pattern aligns with age-related development but differs significantly in epidemiological trends.
OA was not widespread, except in cases of prior injury or disease.
Findings challenge expectations of increasing OA with workload over time, underscoring the interplay of biology and culture in shaping health experiences.