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Acoustically Transparent Sample Containers for Quantitative Cavitation Imaging.

Darcy M Dunn-Lawless, Abigail C Collins, Constantin C Coussios

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
    |September 16, 2025
    PubMed
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    Passive acoustic mapping (PAM) container aberrations distort cavitation imaging. A new container design minimizes these artifacts, improving measurement accuracy for therapeutic applications.

    Area of Science:

    • Acoustics
    • Biomedical Engineering
    • Medical Imaging

    Background:

    • Passive acoustic mapping (PAM) images cavitation activity.
    • Sample containers can introduce artifacts in PAM, affecting accuracy.
    • Accurate cavitation measurement is crucial for therapeutic applications.

    Purpose of the Study:

    • Quantify acoustic effects of common sample containers on PAM.
    • Design and evaluate a new container with improved acoustic transparency.
    • Provide guidelines for selecting containers to minimize PAM artifacts.

    Main Methods:

    • Acoustic reciprocity experiments were used to test six container types.
    • Insertion loss, phase aberration, and energy spread were measured.
    • A novel container was designed and tested with simulated and real cavitation noise.

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    Main Results:

    • Existing containers caused up to 13-dB insertion loss and significant image aberrations.
    • The new container exhibited minimal insertion loss (≤1.6 dB) and no significant aberrations.
    • The new container demonstrated superior acoustic transparency compared to existing options.

    Conclusions:

    • Standard sample containers significantly degrade PAM image quality.
    • The developed container design offers improved acoustic transparency for accurate cavitation measurement.
    • Guidelines for container selection will enhance the reliability of PAM in research and therapy.