Related Experiment Video
Updated: Jan 17, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
Fever Induces Long-Term Synaptic Enhancement and Protects Learning in an Accelerated Aging Model
Fusheng Du1, Qi Wan2, Oleg O Glebov1,3
1Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao 266071, Shandong, China.
None:
The physiological impact of fever on the brain remains poorly understood. Here, we demonstrate that temperature increases by yeast injection in rats (N=9) and by whole-body hyperthermia in mice (N=7) triggers structural synaptic enhancement in the prefrontal cortex through a mechanism involving AMPA-type glutamate receptors and protein translation (N=6). Repeated pyrexia induction in juvenile rats (N=9) results in synaptic strengthening that persists into adulthood, mitigating learning deficits and synaptic loss in a D-galactose model of accelerated aging (N=9-11). Our results show how common environmental conditions may shape brain function in the long-term via synaptic plasticity, warranting further exploration of thermal treatment for cognitive protection in aging.
More Related Videos
11:13Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
Published on: November 29, 2013
09:39Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
Related Concept Videos
Long-term Potentiation
Hebbian LTP
LTP can occur when...
Long-term Potentiation
Long-term Depression
Calcium Ion Concentration Mechanism
If over...
Long-term Depression
Increased Body Temperature
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...