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Exploring APC Mosaicism in Upper Intestinal Tract Adenomas

Diantha Terlouw1,2, Maartje Nielsen2, Jurjen J Boonstra3

  • 1Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.

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|September 16, 2025
PubMed
Summary

No abstract available in PubMed .

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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