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A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

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Intrathecal Baclofen to Improve Functional Status in ALS: A Case Report.

Mark P Pressler¹, Peter S Cooper¹, Whitney Carter¹

¹University of Virginia Department of Anesthesiology, Charlottesville, VA.

Pain Medicine Case Reports

|September 16, 2025

Summary

Intrathecal baclofen (ITB) pumps improved functional status in an amyotrophic lateral sclerosis (ALS) patient with severe spasticity and tremors. The patient experienced increased mobility and reduced symptoms after ITB therapy.

Area of Science:

Neurology
Neurosurgery
Rehabilitation Medicine

Background:

Intrathecal baclofen (ITB) therapy is established for chronic pain and spasticity management.

Keywords:

Amyotrophic lateral sclerosis (ALS)baclofen chronic pain functional status interventional pain intrathecal

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ITB allows significantly lower doses compared to oral baclofen, with comparable efficacy.

Limited evidence exists on ITB's impact on functional status in amyotrophic lateral sclerosis (ALS) patients.