Separation, characterization, AI screening, and bioactivities of marine bioactive peptides: A review

Marine bioactive peptides (MBPs) are short-chain amino acid polymers derived from marine sources that possess specific physiological activities. Owing to their unique origins and structural diversity, MBPs have attracted considerable research interest. This paper therefore provides a systematic review of the latest advances regarding extraction, purification, structural characterization, artificial intelligence (AI)-based screening, biological activities, and structure-activity relationships. Despite notable progress, challenges remain in achieving efficient extraction; implementing effective separation and purification; ensuring adequate sample quantity and quality for AI-based screening; improving model accuracy; and advancing studies of biological activities and structure-activity relationships. Future research should prioritize the development of green, efficient extraction and purification technologies; the construction of more accurate models for bioactive peptide screening; and more in-depth, systematic, and rigorous investigations of biological activities and structure-activity relationships. These efforts will lay a solid foundation for the application of MBPs with well-defined functions in the food, pharmaceutical, and cosmetic sectors.