Related Experiment Video
Updated: Jan 17, 2026
Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma
Published on: September 3, 2021
Postoperative serum VEGF concentration and recurrence after curative colon cancer surgery: findings from a
Clara Téllez1, Meritxell Labró-Ciurans2, Sofía de la Serna3
1Department of General and Digestive Surgery, Hospital del Mar, Barcelona, Spain; Colorectal Cancer Research Group, Hospital del Mar Research Institute, Barcelona, Spain; Department of Surgery, Universitat Autònoma de Barcelona, Barcelona, Spain.
Background:
Angiogenesis is essential for tumor progression, with vascular endothelial growth factor (VEGF) as a key regulator. A prior single-center study identified VEGF >370 pg/mL on postoperative day 4 (POD4) as a predictor of recurrence in colon cancer (CC).
Methods:
We conducted a prospective study including 255 patients undergoing curative-intent CC surgery across seven Spanish institutions (NTC04851054). Serum VEGF was measured via ELISA on POD4.
Results:
After a median follow-up of 34 months, recurrence occurred in 15.7 % of patients. The previously proposed VEGF cutoff was not validated. No significant differences in VEGF were observed between patients with and without recurrence. However, higher VEGF levels were associated with open surgery (p = 0.013) and postoperative complications (p < 0.001), with a trend in anastomotic leakage (p = 0.062).
Conclusions:
VEGF was not predictive of recurrence in this setting but remains a relevant marker of perioperative angiogenic activity, warranting further investigation.
More Related Videos
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
09:24Three-dimensional Angiogenesis Assay System using Co-culture Spheroids Formed by Endothelial Colony Forming Cells and Mesenchymal Stem Cells
Published on: September 18, 2019
