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Harmonic Nanoparticles for Regenerative Research
Published on: May 1, 2014
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Nanoparticle deposition to a cell transiting through a soft tissue: three-dimensional simulation and Lagrangian
Mazyar Dawoodian1, Amalendu Sau1
1Department of Aerospace Engineering, Gyeongsang National University, Jinju-si, Republic of Korea.
Journal of the Royal Society, Interface
|September 16, 2025
Summary
Time-invariant spatial attractors-repellers guide nano-suspensions around tumor cells. Nanoparticle delivery is feasible via the cell
Area of Science:
- Biophysics
- Computational Fluid Dynamics
- Nanomedicine
Background:
- Targeted drug delivery faces challenges due to poor understanding of nanoparticle behavior near cells.
- Active nano-bio-separatrices at the cellular level are crucial for effective nanomedicine delivery.
Purpose of the Study:
- To elucidate the role of time-invariant spatial attractors-repellers in nanoparticle segregation around a tumor cell.
- To understand nanoparticle trajectories and identify geometric separatrices for optimized drug delivery.
Main Methods:
- Lattice-Boltzmann-immersed-boundary method for cell kinematics simulation.
- Dynamical system approach for computing nanoparticle trajectories.
- Particle Lagrangian Coherent Structures (pLCS) analysis to identify separatrices.
Main Results:
- Dominant attractive-repulsive pLCS demarcate regions for nanoparticle attraction/repulsion.
- Nanoparticle delivery is feasible through the stretched plasma membrane's high-tension rear side.
- Repulsive pLCS barricades nanoparticles from the cell's low-tension lateral/front sides.
Conclusions:
- A universal separation behavior of nanoparticles around cells is identified.
- Nanoparticle delivery rate increases with capillary number and cell nucleus size.
- Delivery rate decreases for heavier nanoparticles and stiffer cell nuclei/nuclear envelopes.
