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Decoding immunometabolism with next-generation tools: lessons from dendritic cells and T cells
Yi-Hao Wang1,2, Limei Wang3,4, Ping-Chih Ho5,6,7
1Department of Oncology, University of Lausanne, Lausanne, Switzerland.
The EMBO Journal
|September 16, 2025
Summary
Cellular metabolism critically controls immune cell function and responses. Advanced technologies now reveal how metabolic reprogramming in disease drives immune dysfunction, offering new therapeutic targets.
Area of Science:
- Immunology
- Metabolic pathways
- Cellular biology
Background:
- Cellular metabolism regulates immune cell functions and fate decisions in health and disease.
- Metabolic pathways act as signaling hubs influencing immune cell behavior.
- Dysregulated metabolism contributes to immune dysfunction and disease progression.
Purpose of the Study:
- To summarize cutting-edge technologies for studying immunometabolism.
- To critically assess the limitations of current methods.
- To discuss future needs for novel techniques in immunometabolism research.
Main Methods:
- Quantitative single-cell metabolomics
- In vivo spatial tissue profiling
- Dendritic cell (DC)-based metabolic therapy
Main Results:
- Advanced technologies have revolutionized the understanding of immune cell biology and immunometabolism.
- Focus has shifted to metabolic reprogramming within disease microenvironments.
- Metabolic changes are shown to drive immune cell activation, differentiation, and effector responses.
Conclusions:
- Integrating immunometabolic insights into clinical practice can advance precision medicine.
- Targeted therapies can be developed to restore immune balance in pathological conditions.
- Novel methods are needed to fully uncover the metabolism-immune cell function interplay.
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