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Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
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Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
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Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
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Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
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Related Experiment Video

Updated: Jan 17, 2026

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
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Increasing alignment of large language models with language processing in the human brain.

Changjiang Gao1,2, Zhengwu Ma1, Jiajun Chen2

  • 1Department of Linguistics and Translation, City University of Hong Kong, Hong Kong, China.

Nature Computational Science
|September 16, 2025
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Summary
This summary is machine-generated.

Larger language models (LLMs) better capture human brain activity during reading than instruction-tuned models. Scaling LLMs, not instruction tuning, improves cognitive plausibility for language comprehension studies.

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Area of Science:

  • Cognitive Science
  • Neuroscience
  • Artificial Intelligence

Background:

  • Transformer-based large language models (LLMs) offer insights into brain's meaning representation.
  • Concerns exist regarding the validity of large LLMs due to extensive data and long context access.
  • Instruction tuning is a key LLM technique beyond simple scaling.

Purpose of the Study:

  • Investigate if instruction tuning enhances LLMs' ability to capture human brain's linguistic information.
  • Compare base and instruction-tuned LLMs of varying sizes against human reading data.
  • Assess the cognitive plausibility of LLMs for naturalistic language comprehension.

Main Methods:

  • Compared base and instruction-tuned LLMs (varying sizes) with human data.
  • Utilized eye-tracking and functional magnetic resonance imaging (fMRI) for brain activity.
  • Analyzed data during naturalistic reading tasks.

Main Results:

  • Increasing LLM size, rather than instruction tuning, resulted in a closer match to human brain activity.
  • Base LLMs showed better alignment with human cognitive processes than instruction-tuned models.
  • Model size is a more critical factor than instruction tuning for brain representational similarity.

Conclusions:

  • Scaling LLMs is more effective than instruction tuning for mimicking human brain's linguistic processing.
  • Findings challenge the cognitive plausibility of instruction-tuned LLMs for studying language comprehension.
  • LLM size is a crucial consideration for their application in cognitive neuroscience research.