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Local anesthetic systemic toxicity induced by penile nerve block: A systematic review

Miyeong Park1,2, Soo Hee Lee1,2, Ju-Tae Sohn3,4

  • 1Department of Anesthesiology and Pain Medicine, Gyeongsang National University Changwon Hospital 11, Samjeongja-ro, Seongsan-gu, Changwon-si, Gyeongsangnam-do, Republic of Korea.

Medicine
|September 17, 2025
PubMed
Summary

Local anesthetic systemic toxicity (LAST) from penile nerve blocks is often due to overdose or intravascular absorption, particularly in infants undergoing circumcision. Prompt recognition and treatment, including lipid emulsion, are crucial for recovery.

Keywords:
bupivacaineextreme ageinadvertently intravascular absorptionlidocainelocal anesthetic systemic toxicitylow muscle massoverdosepenile nerve blockrisk factor

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