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Exploring the causal relationship between sedentary behavior and cardiovascular disease: A two-sample Mendelian

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  • 1Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, PR China.

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Summary

Sedentary behavior, like leisure screen time and TV viewing, is causally linked to increased cardiovascular disease risk. Reducing these specific sedentary activities may help prevent heart disease.

Keywords:
Mendelian randomizationcardiovascular diseasecausal effectgenome-wide association studysedentary behavior

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Area of Science:

  • Cardiovascular epidemiology
  • Genetic epidemiology
  • Behavioral science

Background:

  • Cardiovascular disease (CVD) is a leading global cause of mortality.
  • The causal link between sedentary behavior (SB) and CVD outcomes requires further investigation.

Purpose of the Study:

  • To investigate the potential causal relationship between genetically predicted sedentary behaviors and various cardiovascular disease outcomes.
  • To differentiate the CVD risks associated with specific types of sedentary activities.

Main Methods:

  • Utilized Mendelian randomization analysis with summary statistics from FinnGen and UK Biobank.
  • Employed single nucleotide polymorphisms as instrumental variables to assess causal effects.
  • Examined associations between genetically predicted leisure screen time, TV viewing, computer use, driving, and CVD outcomes.

Main Results:

  • Genetically predicted leisure screen time showed significant associations with increased risks of cardiovascular disease (OR=1.13), coronary artery disease (OR=1.18), heart failure (OR=1.10), and ischemic stroke (OR=1.14).
  • Television viewing time was positively associated with cardiovascular disease risk (OR=1.32).
  • No significant causal associations were found for computer use or driving.

Conclusions:

  • This study provides evidence for a causal relationship between leisure screen time, television viewing, and elevated cardiovascular disease risk, particularly coronary artery disease.
  • Findings highlight the importance of targeting specific sedentary behaviors, such as screen time and TV watching, in public health strategies for cardiovascular disease prevention.