Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Study Designs in Epidemiology01:20

Study Designs in Epidemiology

902
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
902
Cause and Effect01:53

Cause and Effect

12.1K
While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
12.1K
Bone Disorders01:29

Bone Disorders

5.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.1K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.0K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.0K
Causality in Epidemiology01:21

Causality in Epidemiology

1.5K
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
1.5K
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

216
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
216

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simple and Versatile Toolkit for Genetic Manipulation of <i>Bacillus licheniformis</i>.

ACS synthetic biology·2025
Same author

[Pathogenicity analysis and genetic counseling for a hemizygous c.1042-10G>C variant of SLC9A7 gene].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·2025
Same author

[Pathogenicity analysis of a novel PADI6 gene variant associated with female infertility].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·2025
Same author

Introducing anti-hydrogen evolution sites by hydrophilic metalloporphyrin coatings for stabilizing Zn metal anodes.

Journal of colloid and interface science·2025
Same author

Cardiac surgery timing on the prognosis of patients with infective endocarditis.

Journal of cardiothoracic surgery·2025
Same author

Association of embolization branch selection on middle meningeal artery embolization for chronic subdural hematoma: a secondary analysis of the MAGIC-MT trial.

Neuroradiology·2025

Related Experiment Video

Updated: Jan 17, 2026

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography
04:24

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography

Published on: November 22, 2017

10.3K

Causality between coffee intake and bone health: A Mendelian randomization study.

Heng Yang1, Liling Yang2, Zongping Li3

  • 1Department of Orthopaedics, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, PR China.

Medicine
|September 17, 2025
PubMed
Summary

This study found no causal link between coffee consumption and osteoarthritis, rheumatoid arthritis, or osteoporosis risk. Mendelian randomization analysis confirmed that coffee intake does not influence the development of these bone and joint conditions.

Keywords:
Mendelian randomizationcoffee intakeosteoarthritisosteoporosisrheumatoid arthritis

More Related Videos

Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

2.5K
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.4K

Related Experiment Videos

Last Updated: Jan 17, 2026

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography
04:24

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography

Published on: November 22, 2017

10.3K
Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

2.5K
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.4K

Area of Science:

  • Genetics
  • Epidemiology
  • Rheumatology

Background:

  • Observational studies suggest associations between coffee intake and osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OP).
  • The causal nature of these observed associations remains unclear.

Purpose of the Study:

  • To investigate the potential causal relationship between coffee intake and the risk of OA, RA, and OP.
  • Utilizing a robust 2-sample bidirectional Mendelian randomization (MR) approach.

Main Methods:

  • A 2-sample bidirectional Mendelian randomization (MR) analysis was performed.
  • Genetic data from large-scale genome-wide association studies (GWAS) including UK Biobank participants were used for OA, RA, OP, and coffee intake.
  • Inverse variance weighting (IVW), MR-Egger, and weighted median methods were employed, with heterogeneity assessed via Cochran's Q statistic and MR-PRESSO for SNP selection.

Main Results:

  • No evidence of a causal relationship was found between coffee intake and the risk of RA (OR: 0.84; 95% CI: 0.24-2.93).
  • Genetic predisposition to coffee intake was not significantly associated with OA (OR: 1.21; 95% CI: 1.01-1.45) or OP (OR: 1; 95% CI: 0.99-1.0).
  • Reverse MR analysis also showed no significant causal effect of OA, RA, or OP on coffee intake.

Conclusions:

  • The findings do not support a causal link between coffee consumption and the risk of developing osteoarthritis, rheumatoid arthritis, or osteoporosis.
  • This study provides robust evidence against a causal role for coffee intake in these prevalent musculoskeletal conditions.