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Updated: Jun 15, 2026

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
Published on: April 21, 2021
Shape Transformation of Poly(l-methionine sulfoxide)-b-poly(dehydroalanine) Vesicles
Casey A Morrison1, Timothy J Deming1,2
1Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.
None:
The controlled transformation of polymeric vesicles into stable nonspherical morphologies is of interest as a means to mimic cells, create nanoreactors, and improve their potential for therapeutic delivery applications. We have found that the poly(dehydroalanine) segments in poly(l-methionine sulfoxide)x-b-poly(dehydroalanine)y, MOxADHy, copolypeptides form membranes that provide plasticity and selective permeability in DMSO/water mixtures, which allow the predictable control of vesicle shape by the variation of dialysis conditions. The findings of this study expand vesicle shape transformation methods to these biodegradable block copolypeptide vesicles, which are amenable to development for applications in therapeutic delivery.
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