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Updated: Jan 6, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Multicomponent Synthesis of Isoquinuclidines via Pd-Catalyzed Selective Dechlorination
Qixin Zhou1, Guocong Zhang1, Yingqi Lan1
1Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, P. R. China.
None:
We report a visible-light palladium-catalyzed multicomponent reaction enabling efficient synthesis of 2-azabicyclo[2.2.2]octenes via a multicomponent coupling of cyclic 1,3-dienes, gem-dichloroalkanes, and amines. Mechanistic studies indicate a radical pathway with selective dechlorination and high 1,4-syn diastereoselectivity. This mild, efficient method provides sp3-rich bicyclic scaffolds amenable to further derivatization. Its utility is demonstrated in concise syntheses of bioactive alkaloids, including deethylibogamine and Rauwolfia analogues, highlighting its potential for complex molecule construction in medicinal chemistry.
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