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Functional interaction between immune checkpoints and lipid metabolism in the development of arteriosclerosis

Junyi Zhang1, Liyuan Cui2,3,4, Xinhang Meng2,3,4

  • 1Department of Interventional Vascular Surgery, Xinhua Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai, China.

Frontiers in Immunology
|September 17, 2025
PubMed

Insights

Arteriosclerosis obliterans (ASO) involves complex lipid metabolism and inflammation. Immune checkpoints regulate lipid metabolism, influencing ASO progression and offering potential therapeutic targets.

Area of Science:

  • Vascular Biology
  • Immunology
  • Metabolic Disorders

Background:

  • Arteriosclerosis obliterans (ASO) is a chronic vascular disease causing limb loss.
  • ASO pathogenesis involves lipid metabolism disorders and chronic inflammation.
  • Immune checkpoints are key regulators of the immune microenvironment in ASO.

Purpose of the Study:

  • To review the role of immune checkpoints in ASO.
  • To discuss how immune checkpoints influence lipid metabolism in ASO.
  • To identify potential therapeutic targets by exploring interactions between lipid metabolism and immune checkpoints.

Main Methods:

  • Literature review and synthesis of current research.
  • Analysis of the interplay between immune checkpoints and lipid metabolism pathways.
  • Discussion of the implications for ASO pathogenesis and treatment.

Main Results:

  • Immune checkpoints significantly impact the immune microenvironment in ASO.
  • Immune checkpoints modulate immune cell metabolism, affecting lipid absorption, transport, and degradation.
  • This regulation of lipid metabolism by immune checkpoints plays a crucial role in ASO development and progression.

Conclusions:

  • Immune checkpoints are critical regulators in ASO, influencing lipid metabolism.
  • Understanding the interaction between lipid metabolism and immune checkpoints is vital for ASO management.
  • Further research may reveal novel therapeutic strategies targeting these pathways for ASO.

Keywords:
arteriosclerosis obliteransendothelial functionimmune checkpointslipid metabolismvascular inflammatory responses

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