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Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
Glycine Betaine-Functionalized Ionic Liquids: Design of Versatile Bioplatform for Incorporating Biologically Active
Witold Stachowiak1, Marcin Wysocki2, Lorenzo Guazzelli3
1Faculty of Chemical Technology, Poznan University of Technology, Poznan 60-965, Poland.
Abstract:
We report a novel series of ILs formed by coupling glycine betaine with the biologically active herbicide MCPA via an ester bond. ILs were synthesized through a 2-step O-alkylation process, followed by product isolation using flash chromatography. The alkyl chain length between the carboxylic groups determines solubility and octanol-water partition coefficient, whereas the rate of their hydrolysis is highly influenced by the pH of aqueous solution. All compounds retained the biological activity of the incorporated herbicide.
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