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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Related Experiment Video

Updated: May 6, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Radiation Therapy for Local or Biochemical Recurrence Following Radical Prostatectomy in Patients with Prostate

Hiroki Nishiyama1, Gen Kawaguchi2, Kozue Ito3

  • 1Department of Urology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma, Niigata, Japan.

Research and Reports in Urology
|September 17, 2025
PubMed
Summary

Androgen deprivation therapy (ADT) may help prevent recurrence after radiation therapy for prostate cancer recurrence. Prostate-specific antigen doubling time (PSADT) is a useful factor when considering salvage radiation therapy for biochemical recurrence.

Keywords:
biochemical recurrencelocal recurrenceprostate cancerprostatectomyradiation therapy

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Urology

Background:

  • Radical prostatectomy is a primary treatment for prostate cancer.
  • Biochemical or local recurrence can occur after prostatectomy.
  • Salvage radiotherapy is a treatment option for recurrent prostate cancer.

Purpose of the Study:

  • To investigate outcomes of patients with biochemical or local recurrence after radical prostatectomy.
  • To evaluate the effectiveness of salvage radiotherapy to the prostate bed.
  • To assess the role of androgen deprivation therapy (ADT) and PSA doubling time (PSADT) in recurrence-free survival.

Main Methods:

  • Patients with suspected recurrence underwent imaging for local recurrence and distant metastasis.
  • Salvage radiotherapy was administered to the prostate bed (64.8 Gy) or the site of local recurrence plus the prostate bed (70.8 Gy + 64.8 Gy).
  • The impact of ADT and PSADT on clinical recurrence-free survival was analyzed.

Main Results:

  • None of the 10 patients receiving ADT during radiation therapy experienced recurrence, compared to 3 of 9 patients who did not receive ADT.
  • No significant difference in recurrence-free survival was observed between patients receiving radiation therapy alone versus those receiving ADT during radiation therapy (p = 0.302).
  • Patients with a PSADT of ≥6 months showed a trend towards longer recurrence-free survival after salvage radiation therapy compared to those with PSADT <6 months (p=0.06).

Conclusions:

  • ADT may be beneficial in preventing recurrence following radiation therapy for local recurrence after radical prostatectomy.
  • PSADT may be a useful prognostic factor when considering salvage radiation therapy for patients with biochemical recurrence.
  • Further research with larger sample sizes is warranted.