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[Immunostructure of the population to the influenza C virus]
Insights
Maternal antibodies protect infants from influenza C virus until 6 months. Children aged 6 months to 7 years are most susceptible, while most adults exhibit immunity.
Area of Science:
- Virology
- Immunology
- Epidemiology
Context:
- Influenza C virus poses a significant public health concern, particularly in pediatric populations.
- Understanding age-related immunity is crucial for developing effective prevention and control strategies.
- Previous research has not fully elucidated the seroprevalence and age-specific susceptibility to influenza C virus in the USSR population.
Purpose:
- To investigate the seroprevalence of influenza C virus antibodies across different age groups in the USSR.
- To determine the age at which active immune responses to influenza C virus develop and persist.
- To identify age-specific susceptibility patterns to influenza C virus infection.
Summary:
- A study examined 842 pediatric and 975 adult serum specimens.
- Infants under 6 months possess maternal antibodies, while active immunity develops from 6 months to 14 years.
- Children aged 6 months to 7 years showed the highest susceptibility, whereas 85.7% of adults had antibodies, with Moscow showing the highest prevalence.
Impact:
- This research provides critical insights into the immunological landscape of influenza C virus in the USSR.
- Findings can inform targeted vaccination strategies and public health interventions for vulnerable age groups.
- Establishes a baseline for future influenza C virus surveillance and research in the region.
Abstract:
Examinations of 842 blood serum specimens from children varying in age from 0 to 14 years and 975 blood serum specimens from adults of 20-60 were carried out. The infants of 0-6 months of age may be considered to be immunologically protected by passively transmitted maternal antibodies. The formation of active immune response occurs at the age of 6 months to 14 years with subsequent antibody persistence and additional latent immunization in older age. Children of 6 months to 7 years are most susceptible to infection with influenza C virus. Among the adult USSR population, antibody to influenza virus was found in approximately 85.7% of subjects. The proportion of seropositive subjects varied in different parts of the country. The greatest numbers of positive findings and high levels of antibody to influenza C virus were found in the adult and child population of Moscow.