Nanozyme-Engineered Probiotic Microneedle Patch for Chronic Diabetic Wound Therapy.
Xueyang Wang1, Shuhua Liu1, Shisuo Jing1
1Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital), School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, P. R. China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|September 17, 2025
Summary
A novel microneedle patch delivers platinum nanozyme-engineered probiotics to heal chronic diabetic wounds by fighting infection, reducing inflammation, and improving tissue repair. This living-materials approach shows promise for clinical application.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Microbiology
Background:
- Chronic diabetic wounds present significant healing challenges due to bacterial infections, oxidative stress, and hypoxia.
- Current treatments often fall short in addressing the complex multifactorial nature of these wounds.
Purpose of the Study:
- To develop and evaluate a multifunctional probiotic microneedle (MN) patch for synergistic diabetic wound therapy.
- To investigate the efficacy of platinum nanozyme-engineered Bacillus subtilis (Pt-M@B. sub) for wound healing.
Main Methods:
- Fabrication of a dissolvable microneedle patch embedding Pt-M@B. sub in a biocompatible polymer matrix.
- Transdermal delivery of the MN patch to the wound bed for minimally invasive treatment.
- Assessment of antibacterial activity, anti-inflammatory effects, tissue repair promotion, and biosafety.
Main Results:
- The Pt-M@B. sub MN patch effectively suppressed Staphylococcus aureus infection and reduced inflammation.
- The treatment promoted collagen deposition and angiogenesis, accelerating wound closure.
- Biosafety assessments confirmed excellent biocompatibility and systemic safety, with demonstrated skin penetration and delivery potential.
Conclusions:
- This living-materials strategy integrates microbial therapy with catalytic nanotechnology for effective chronic infected wound management.
- The probiotic MN patch demonstrates significant potential for clinical translation in treating diabetic wounds.
