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Published on: February 8, 2019
TNF-alpha inhibitor therapy for granuloma annulare
Najiba Afzal1, Waqas Burney2, Raja K Sivamani2,3,4
1School of Medicine, University of California, Davis, CA, USA.
Tumor necrosis factor-alpha (TNF-a) inhibitors show promise for treating granuloma annulare (GA). Medications like etanercept and adalimumab are effective for GA unresponsive to other treatments.
Area of Science:
- Dermatology
- Immunology
Background:
- Granuloma annulare (GA) presents as inflammatory, annular skin lesions.
- The exact cause of GA remains unknown, making treatment difficult.
- Current therapies include topical/intralesional steroids and biologics.
Purpose of the Study:
- To review the existing literature on TNF-alpha inhibitor therapy for GA treatment.
Main Methods:
- Literature review of studies investigating TNF-alpha inhibitors for GA.
Main Results:
- Granuloma annulare demonstrates a positive response to TNF-alpha inhibitors.
- Etanercept and adalimumab are particularly noted for their efficacy.
Conclusions:
- TNF-alpha inhibitors offer a viable treatment option for refractory GA.
- These findings support dermatologists in managing GA cases resistant to conventional therapies.
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