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Published on: February 8, 2019
TNF-alpha inhibitor therapy for granuloma annulare
Najiba Afzal1, Waqas Burney2, Raja K Sivamani2,3,4
1School of Medicine, University of California, Davis, CA, USA.
Background:
Granuloma annulare (GA) is an inflammatory cutaneous reaction characterized by erythematous, annular skin lesions. The etiology of GA is unknown, and treatment is challenging. The current treatment options include topical or intralesional steroids. Biologics can also be effective.
Methods:
In this paper, we review the current literature on the use of TNF-alpha inhibitor therapy in the treatment of GA.
Results/Conclusion:
GA has a positive response to TNF-alpha inhibitors, most notably with etanercept and adalimumab. These findings can aid dermatologists in treating GA that is unresponsive to other therapies.
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