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Evaluation of Pediatric Cardiomyopathy Patients in Pediatric Intensive Care Unit

Şeyda Kesen1, Merve Havan2, Mehmet Ramoğlu3

  • 1Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Türkiye.

Turkish Archives of Pediatrics
|September 17, 2025
PubMed

Insights

Pediatric cardiomyopathies (CMP) often lead to severe heart failure, requiring intensive care, mechanical ventilation, and advanced circulatory support like ECMO and LVAD. Outcomes remain poor, with over half of patients in this study dying despite aggressive treatments.

Area of Science:

  • Pediatric Cardiology
  • Intensive Care Medicine
  • Cardiovascular Research

Background:

  • Cardiomyopathies (CMP) are a significant cause of end-stage heart failure in children.
  • Understanding the clinical course and treatment needs of pediatric CMP patients in the intensive care setting is crucial.

Purpose of the Study:

  • To evaluate the clinical features, treatments, and outcomes of pediatric patients diagnosed with CMP.
  • To analyze the utilization of intensive care resources and advanced therapies in managing severe pediatric heart failure due to CMP.

Main Methods:

  • Retrospective analysis of 76 pediatric patients diagnosed with CMP admitted to the pediatric intensive care unit (PICU) between 2008 and 2019.
  • Data collected included demographics, CMP type, diagnostic findings, medical and respiratory/circulatory support, cardiac transplantation, and patient outcomes.

Main Results:

  • Dilated cardiomyopathy was the most common type (68.4%).
  • The majority of patients required diuretics (90.8%), inotropes (93.4%), and invasive mechanical ventilation (75%).
  • Advanced support included extracorporeal membrane oxygenation (ECMO) in 43.4%, left ventricular assist device (LVAD) in 15.8%, and biventricular assist device (BiVAD) in 2.6%; 13.2% underwent heart transplantation, with a mortality rate of 52.6%.

Conclusions:

  • Pediatric CMP patients with severe heart failure necessitate intensive care with advanced interventions like mechanical ventilation, ECMO, LVAD, BiVAD, and heart transplantation.
  • Despite aggressive management, mortality remains high, highlighting the critical need for specialized pediatric intensive care and ongoing research into novel therapies.

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