Choroidal vascular hyperpermeability patterns in central serous chorioretinopathy correlate with microperimetry:...

Area of Science:

• Ophthalmology
• Retinal Imaging
• Choroidal Vasculature

Background:

• Central serous chorioretinopathy (CSC) is a condition affecting the retina.
• Choroidal vascular hyperpermeability (CVH) patterns on indocyanine green angiography (ICGA) may indicate disease chronicity.
• Previous research suggests a link between CVH patterns and disease duration.

Purpose of the Study:

• To evaluate the association between three distinct CVH leakage patterns (uni-FISH, multi-FISH, DISH) on ICGA and retinal sensitivity in CSC patients.
• To determine if these patterns correlate with macular sensitivity measured by microperimetry.

Main Methods:

• Retrospective analysis of 154 eyes from 91 CSC patients (CERTAIN study).
• Utilized ultra-widefield (UWF) and 55° ICGA, alongside comprehensive multimodal imaging including microperimetry.
• Independent grading of CVH patterns, with adjudication for disagreements.

Main Results:

• Diffuse leakage (DISH) was associated with significantly lower macular sensitivity compared to unifocal indistinct signs of hyperpermeability (uni-FISH) on both UWF and 55° ICGA.
• Lower sensitivity was also observed when comparing DISH to a combined uni- and multifocal FISH group.
• Statistical significance (p<0.05) was found for these associations.

Conclusions:

• CVH patterns (uni-FISH, multi-FISH, DISH) are strongly associated with retinal sensitivity levels in CSC patients.
• The diffuse leakage pattern (DISH) shows a notable reduction in macular sensitivity.
• ICGA patterns may serve as valuable tools for assessing CSC disease severity and predicting functional outcomes.