Role of long non-coding RNAs in the pathogenesis of gastric cancer-induced by Helicobacter pylori
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View abstract on PubMed
Summary
This summary is machine-generated.Long non-coding RNAs (lncRNAs) are key players in Helicobacter pylori-associated gastric cancer (GC) development. These molecules promote tumorigenesis by affecting cell growth and inflammation, offering potential as diagnostic and therapeutic targets.
Area Of Science
- Molecular Biology
- Oncology
- Genetics
Background
- Gastric cancer (GC) is a major global health issue, with Helicobacter pylori (H. pylori) infection as a primary risk factor.
- The molecular mechanisms linking H. pylori infection to GC pathogenesis are complex and under investigation.
- Long non-coding RNAs (lncRNAs) are emerging as critical regulators of gene expression in various biological processes, including cancer.
Purpose Of The Study
- To provide a comprehensive overview of the role of lncRNAs in the pathogenesis of H. pylori-induced gastric cancer.
- To elucidate the molecular mechanisms by which lncRNAs contribute to H. pylori-associated GC.
- To highlight the potential of lncRNAs as biomarkers and therapeutic targets.
Main Methods
- Literature review and synthesis of existing research on lncRNAs in H. pylori-associated GC.
- Analysis of specific upregulated lncRNAs (e.g., H19, GClnc1, LINC00152, PVT1) and their functions.
- Examination of lncRNA regulatory mechanisms, including epigenetic, transcriptional, and post-transcriptional effects.
Main Results
- Upregulated lncRNAs (H19, GClnc1, LINC00152, PVT1) promote GC tumorigenesis by enhancing proliferation, migration, invasion, and inflammation.
- lncRNAs interact with oncogenic pathways (Wnt/β-catenin, PI3K/AKT, NF-κB), stabilize oncoproteins, and sequester tumor-suppressive microRNAs.
- H. pylori-induced lncRNAs contribute to DNA damage, genomic instability, angiogenesis, and immune evasion, shaping the tumor microenvironment.
Conclusions
- lncRNAs play a multifaceted role in H. pylori-associated GC pathogenesis.
- lncRNAs are implicated in key cellular processes, signaling pathways, and the tumor microenvironment.
- lncRNAs represent promising diagnostic, prognostic, and therapeutic markers for H. pylori-associated GC, necessitating further research for clinical applications.
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