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Development and Testing of a Self-Paced Virtual Reality-Based Naloxone Training
Wasantha Jayawardene1, Chesmi Kumbalatara1, Matthew Kase2
1School of Human Sciences, Southern Illinois University, Carbondale, IL, USA.
Substance Use & Misuse
|September 17, 2025
Summary
Virtual Reality Naloxone Training (VeNT) enhances overdose response skills and confidence for laypersons. This immersive mixed reality approach offers a scalable, engaging alternative to traditional training methods.
Area of Science:
- Medical Education
- Public Health
- Immersive Technologies
Background:
- Increased naloxone availability necessitates scalable training solutions.
- Current training methods face challenges in improving self-efficacy and reducing anxiety for laypersons.
- A gap exists in interactive platforms for overdose reversal training.
Purpose of the Study:
- To develop and evaluate a self-paced Virtual Reality Naloxone Training (VeNT) program.
- To assess the usability and acceptability of VeNT among diverse participants.
- To enhance self-efficacy and reduce anxiety in responding to opioid overdoses.
Main Methods:
- Developed a mixed reality (MR) application, VeNT, using Apple Vision Pro.
- Field tested VeNT in various settings with 25 diverse participants.
- Utilized pre-post surveys and qualitative interviews to assess effectiveness.
Main Results:
- VeNT significantly improved knowledge of overdose recognition and confidence in naloxone administration.
- Participants reported increased intent to help and reduced uncertainty during overdose events.
- VeNT was perceived as more engaging and effective than traditional training methods.
Conclusions:
- VeNT provides a cost-effective, scalable solution for naloxone training.
- Mixed reality-based training demonstrates feasibility and engagement for diverse populations.
- VeNT effectively boosts knowledge and confidence in overdose response.

