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Elevated Resting Heart Rate Is an Independent Risk Factor for Mortality in Patients with Colorectal Cancer: A
Wonhee Cho1,2, Ho Seung Kim3, Dong Hoon Lee1,4
1Department of Sport Industry Studies, Yonsei University, Seoul, South Korea.
Elevated resting heart rate (RHR) in colorectal cancer patients before surgery is linked to increased mortality risk. Higher RHR predicts both all-cause and cancer-specific deaths, suggesting its clinical relevance.
Area of Science:
- Oncology
- Cardiology
- Epidemiology
Background:
- Lifestyle factors influence resting heart rate (RHR).
- The association between RHR and mortality in colorectal cancer (CRC) patients remains unclear.
- This study investigates RHR's impact on CRC patient survival.
Purpose of the Study:
- To determine if RHR is associated with all-cause mortality in stage I-III CRC patients.
- To assess the link between RHR and CRC-specific mortality in these patients.
Main Methods:
- Included 3,631 patients who underwent surgery for stage I-III CRC.
- Collected RHR data on the day of surgery.
- Utilized multivariable Cox proportional hazards models to analyze mortality risks.
Main Results:
- A median follow-up of 3.0 years revealed 292 all-cause and 177 CRC-specific deaths.
- Highest RHR quintile (≥88 bpm) showed a 3.33-fold increased risk of all-cause mortality.
- Every 10-bpm RHR increase correlated with a 1.44-fold rise in all-cause mortality and 1.50-fold in CRC-specific mortality.
Conclusions:
- Elevated RHR on the day of colorectal cancer surgery is associated with increased mortality.
- RHR may serve as a significant clinical predictor for mortality in patients undergoing CRC surgery.
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