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Artificial intelligence and medical diagnosis: past, present and future
Edward P Hoffer1, Cornelius A James2, Andrew Wong3
1Laboratory of Computer Science, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Diagnosis (Berlin, Germany)
|September 17, 2025
Summary
Artificial intelligence (AI) in diagnosis, when integrated into clinical workflows, shows promise for reducing diagnostic errors. This paper reviews the history, current state, and future potential of AI-driven diagnostic support systems.
Area of Science:
- Medical Informatics
- Artificial Intelligence in Medicine
- Clinical Decision Support
Background:
- Health information technology (HIT) can reduce diagnostic error, as suggested by the NASEM report.
- Computer-based diagnostic decision support systems (CDSS) have a long history but limited clinical impact.
- Current research highlights the potential of AI-enabled CDSS.
Purpose of the Study:
- To review the historical development of AI in medical diagnosis.
- To analyze the current landscape of AI-enabled diagnostic decision support systems.
- To anticipate the future role of AI in reducing diagnostic error.
Main Methods:
- Literature review of historical and current research on AI in diagnosis.
- Analysis of the integration of AI-enabled CDSS into clinical workflows.
- Discussion of the potential impact of AI on diagnostic error reduction.
Main Results:
- AI-enabled decision support systems, when properly integrated, are expected to play an increasing role in reducing diagnostic errors.
- Despite a long history, CDSS have not significantly impacted clinical practice to date.
- AI holds significant promise for improving diagnostic accuracy.
Conclusions:
- Careful implementation of health information technology, particularly AI-enabled systems, is crucial for reducing diagnostic error.
- AI-driven diagnostic tools are poised to become integral to clinical practice.
- The future of diagnosis will likely involve advanced AI support systems.
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