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Updated: Jan 6, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Visible-light-induced cascade cyclization of N-acrylohydrazides toward functionalized pyrazolones and the application
Sheng Yu1, Yangjian Cheng1, Changduo Pan1,2
1School of Petrochemical Engineering, Changzhou University, Changzhou 213164, P. R. China. yujintao@cczu.edu.cn.
Abstract:
A photocatalytic radical cascade cyclization of N-acryloylhydrazides with α-bromoketones was developed. A series of 4-(3-oxo-3-phenylpropyl)-1H-pyrazol-5(4H)-ones were formed in moderate to good yields. α-Bromo difluoroacetamides and 2-bromoacetonitrile were also suitable reaction partners. Late-stage modifications of several drug molecules were also achieved through our strategy.
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