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Updated: Jan 17, 2026

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018
An ingenious suprachoroidal injector based on the resistance feedback theory for treatment of macular edema: A
Dandan Zhang1,2, Qiuyi Zhu1,2, Rong Huang1,2
1Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Abstract:
PurposeTo explore a new suprachoroidal space (SCS) injection technique using an ingenious, handmade, and precise suprachoroidal injector based on the resistance feedback theory to treat recurrent macular edema.MethodsWe designed a suprachoroidal injector on the basis of the resistance feedback theory and fabricated it with readily available commercial materials. Nine patients with recurrent macular edema secondary to diabetic retinopathy or retinal vein occlusion who could not afford repeated anti-vascular endothelial growth factor treatment received suprachoroidal injection of triamcinolone acetonide using this injector. Changes in SCS, macular edema and visual acuity before and after injection were evaluated.ResultsIn all patients, anterior-segment optical coherence tomography revealed SCS expansion immediately after injection. At 1 month after injection, spectral-domain optical coherence tomography revealed a reduction in macular edema with average central subfield thickness decreasing from 574.56 ± 151.53 μm to 338.78 ± 61.26 μm, and best-corrected visual acuity improved from 0.87 ± 0.29 logMAR to 0.55 ± 0.24 logMAR. Complications such as increased intraocular pressure, cataract, retinal damage and fluid injection into the vitreous cavity were not observed.ConclusionsThis new injector is expected to provide an economical, safe, and precise SCS injection and may have potential for widely clinical application.

