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Related Concept Videos

Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

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Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Updated: Jan 17, 2026

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
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Dynamic pseudo-continuous arterial spin labeling angiography using a 3D-radial multi-spoke spoiled gradient-recalled

Andreas Petrovic1,2, Martin Soellradl1,2, Thomas W Okell3

  • 1Department of Radiology, Monash Health, Clayton, Victoria, Australia.

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A new time-resolved pseudo-continuous arterial spin labeling (ASL) angiography MRI sequence offers high spatial and temporal resolution for identifying vascular lesions. This novel technique improves diagnostic accuracy for intracranial high-flow vascular lesions.

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3D‐radialDAVFPCASLangiographymulti‐spoke

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Area of Science:

  • Neuroradiology
  • Medical Imaging
  • Vascular Imaging

Background:

  • Accurate identification of arterial feeders and draining veins is crucial for managing intracranial high-flow vascular lesions.
  • Existing MRI sequences often lack the necessary temporal and spatial resolution for comprehensive assessment.
  • Novel imaging techniques are needed to improve diagnostic capabilities.

Purpose of the Study:

  • To develop and assess a novel time-resolved pseudo-continuous arterial spin labeling (ASL) angiography sequence.
  • To evaluate its image quality metrics for clinical performance in identifying intracranial high-flow vascular lesions.
  • To compare its resolution and efficiency against standard-of-care sequences.

Main Methods:

  • A novel time-resolved ASL sequence with multi-spoke readouts and dynamic, sliding-window reconstruction was implemented.
  • Image quality was assessed using Likert scales, SNR, and SNR efficiency in ten volunteers and eight patients.
  • Spatial/temporal resolution and acquisition time were compared with time-of-flight (TOF) MRA and contrast-enhanced (CE)-MRA.

Main Results:

  • The novel ASL sequence achieved high isotropic spatial resolution (0.68 mm³) and temporal resolution (200 ms).
  • It demonstrated superior spatial and temporal resolution compared to CE-MRA and comparable spatial resolution to TOF MRA.
  • Multi-spoke acquisitions significantly increased SNR and SNR efficiency, reducing scan time by 31% compared to single-spoke.

Conclusions:

  • The study confirms the clinical feasibility of the novel time-resolved ASL sequence.
  • The sequence provides sufficient SNR, superior resolution to CE-MRA, and comparable resolution to TOF MRA.
  • This technique offers a promising tool for evaluating intracranial high-flow vascular lesions within a clinically practical timeframe.