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Related Concept Videos

Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

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Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
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ATP Driven Pumps II: P-type Pumps01:34

ATP Driven Pumps II: P-type Pumps

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The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
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Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

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Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
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Skeleton and Calcium Homeostasis01:21

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

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Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
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SERCA3, ubiquitous but specific calcium pumps?

Maëliss Toth1, Shaymaa Alhabib2, Boris Manoury1

  • 1Université Paris-Saclay, Inserm, UMR-S 1180, Orsay 91400, France.

Cell Calcium
|September 17, 2025
PubMed
Summary

Sarco-Endoplasmic Reticulum Ca2+-ATPase 3 (SERCA3) pumps are crucial for calcium homeostasis. This review details SERCA3 structure, function, and its role in diseases like obesity and cancer.

Keywords:
CalciumPathophysiologySERCA3

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Physiology

Background:

  • Calcium ions (Ca2+) are vital second messengers regulating cellular functions.
  • Maintaining calcium homeostasis is essential for organismal health.
  • Sarco-Endoplasmic Reticulum Ca2+-ATPases (SERCA) are key transporters regulating calcium levels in the sarcoplasmic or endoplasmic reticulum.

Purpose of the Study:

  • To provide a comprehensive overview of the Sarco-Endoplasmic Reticulum Ca2+-ATPase 3 (SERCA3) pump.
  • To detail SERCA3's structure, gene, protein, and catalytic properties.
  • To explore SERCA3's pathophysiological roles and implications in diseases.

Main Methods:

  • Literature review of existing research on SERCA3.
  • Analysis of SERCA3 gene and protein structure.
  • Examination of SERCA3's functional and pathophysiological studies.

Main Results:

  • SERCA3 is a distinct isoform with unique features compared to SERCA1 and SERCA2.
  • SERCA3 plays a functional role in various organs.
  • Emerging evidence links SERCA3 to diseases including obesity and cancers.

Conclusions:

  • SERCA3 is a critical component of calcium regulation with significant implications for human health.
  • Further research into SERCA3's mechanisms and disease associations is warranted.