Hydrogen ion concentration of tear fluid in newborn infants
Related Experiment Video
Updated: Oct 9, 2026

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
Published on: December 30, 2025
Insights
Newborn infant tear pH was measured, revealing a median value of 6.8. This easy and reliable method helps understand tear function in infants.
Area of Science:
- Ophthalmology
- Neonatology
- Physiology
Background:
- Tear pH is a crucial indicator of ocular surface health.
- Understanding normal tear pH in newborns is essential for diagnosing potential ocular conditions.
- Previous research on neonatal tear pH is limited.
Purpose of the Study:
- To determine the normal tear pH range in newborn infants.
- To establish a reliable method for measuring tear pH in neonates.
- To investigate factors influencing tear pH in newborns.
Main Methods:
- Tear pH was measured in 173 newborn infants using a microcombination glass pH probe.
- The probe was immersed in the tear fluid within the closed lower conjunctival sac.
- Data was collected and analyzed for median and mean pH values, along with interpercentile ranges.
Main Results:
- The median tear pH was 6.8, with a 95% interpercentile range of 6.2 to 7.2.
- The mean tear pH was 6.74 +/- 0.26 (SD).
- Tear pH was not significantly related to infant age (within 12 days), mode of delivery, or silver nitrate application.
Conclusions:
- The microcombination glass pH probe offers an easy and reliable method for assessing tear fluid pH in newborns.
- This study provides valuable reference data for normal tear pH in neonates.
- The findings may enhance the understanding of tear function in both normal and pathological neonatal ocular conditions.
Abstract:
Tear pH was measured in 173 newborn infants by immersing the tip of a microcombination glass pH probe in the tear fluid lateral in the closed lower conjunctival sac. The median tear pH value was 6.8 with 95% interpercentile range 6.2 to 7.2. The mean tear pH value was 6.74 +/- 0.26 (SD). The pH value was not related to age within the first 12 days and not influenced by the mode of delivery or local application of 0.67% argenti nitratis. This method is an easy, reliable examination to record the pH values of tear fluid, and may widen the knowledge of tear function in normal and pathological conditions.
Related Concept Videos
Water: A Bronsted-Lowry Acid and Base
pH Scale
Weak Acid Solutions
Polyprotic Acids
Solubility Equilibria: Ionic Product of Water
The ionic product of water varies with temperature, and its value is 1.0 x 10−14 at standard experimental conditions. Per Le Chatelier's...
Composition of Body Fluids

