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Updated: Jan 17, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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[Research progress on the functional polarization mechanism of myeloid-derived cells in the tumor microenvironment

Chuangchuang Li1, Jingchang Li1, Xiaorui Li1

  • 1The First Clinical Medical College, Henan University of Chinese Medicine, Clinical Laboratory of the First Affiliated Hospital, Henan University of Chinese Medicine, Zhengzhou 450000, China.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology
|September 17, 2025
PubMed

Myeloid-derived cells (MDCs) are crucial in immune response and tissue homeostasis. They have high functional plasticity and can be polarized according to microenvironment signals. These cells, including macrophages, neutrophils, and dendritic cells (DCs), exhibit different functional polarization states in different pathological environments and are involved in the occurrence and development of diseases such as inflammation and tumors. Studies have shown that metabolic reprogramming plays a key role in the functional polarization of MDCs, affecting the cellular energy supply and regulating immune function. This paper reviews classification, function and polarization mechanism of MDCs and discusses metabolic reprogramming. In addition, the therapeutic strategies targeting MDC are summarized, which is expected to provide new targets for tumor immunotherapy.

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