Augmenting conventional criteria: a CT-based deep learning radiomics nomogram for early recurrence risk
Ziqian Wu1, Danyang Liu2, Siyu Ouyang3
1Department of Radiology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen radiological Control Center, Xiamen, China.
Background:
We developed a deep learning radiomics nomogram (DLRN) using CT scans to improve clinical decision-making and risk stratification for early recurrence of hepatocellular carcinoma (HCC) after transplantation, which typically has a poor prognosis.
Materials And Methods:
In this two-center study, 245 HCC patients who had contrast-enhanced CT before liver transplantation were split into a training set (n = 184) and a validation set (n = 61). We extracted radiomics and deep learning features from tumor and peritumor areas on preoperative CT images. The DLRN was created by combining these features with significant clinical variables using multivariate logistic regression. Its performance was validated against four traditional risk criteria to assess its additional value.
Results:
The DLRN model showed strong predictive accuracy for early HCC recurrence post-transplant, with AUCs of 0.884 and 0.829 in training and validation groups. High DLRN scores significantly increased relapse risk by 16.370 times (95% CI: 7.100-31.690; p < 0.001). Combining DLRN with Metro-Ticket 2.0 criteria yielded the best prediction (AUC: training/validation: 0.936/0.863).
Conclusion:
The CT-based DLRN offers a non-invasive method for predicting early recurrence following liver transplantation in patients with HCC. Furthermore, it provides substantial additional predictive value with traditional prognostic scoring systems.
Critical Relevance Statement:
AI-driven predictive models utilizing preoperative CT imaging enable accurate identification of early HCC recurrence risk following liver transplantation, facilitating risk-stratified surveillance protocols and optimized post-transplant management.
Key Points:
A CT-based DLRN for predicting early HCC recurrence post-transplant was developed. The DLRN predicted recurrence with high accuracy (AUC: 0.829) and 16.370-fold increased recurrence risk. Combining DLRN with Metro-Ticket 2.0 criteria achieved optimal prediction (AUC: 0.863).
