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Implementation of the 2024 revision of the McDonald criteria for multiple sclerosis

Marcello Moccia1,2,3, Olga Ciccarelli4,5,6, Alan Thompson4,6

  • 1Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Naples, Italy. marcello.moccia@unina.it.

Nature Reviews. Neurology
|September 17, 2025
PubMed
Abstract

No abstract available in PubMed .

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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